
Research	Publications	Members	Links	Miscellaneous

Selected Publications (total 201 papers, April, 2005)

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Peptide transport

1. Lubkowitz, M., Breslav, M., Naider, F., and Becker, J. M. 1998. Schizosaccharomyces pombe ISP4 encodes a transporter representing a novel family of oligopeptide transporters. Mol. Microbiol.28:729-741. (PubMed)

2. Hauser, M., Narita, V., Donhardt, A.M., Naider, F. and Becker, J.M. 2001. Multiplicity and Regulation of Genes Encoding Peptide Transporters in Saccharomyces cerevisiae. Mol. Mem. Biol. 18:105-112.(PubMed)

3. Stacey, G., Koh, S., Granger, C., and Becker, J.M. 2002 Peptide transport in plants. Trends Plant Sci. 6:257-263.(PubMed)

4. Hauser, M., Kauffman, S., Naider, F., and Becker, J. M. 2005. Substrate preference is altered by mutations in the fifth transmembrane domain of Ptr2p, the di/tri-peptide transporter of Saccharomyces cerevisiae. Mol. Mem. Biol. 22:215-227. (Pubmed)

G Protein-Coupled Receptors

1. Akal-Strader, A., Khare, S., Xu, D., Naider, F., and Becker, J.M. 2002. Residues in the First Extracellular Loop of a G Protein-Coupled Receptor Play a Role in Signal Transduction J. Biol. Chem. 277: 30581-30590. (PubMed)

2. Lee, B.K., Lee, Y.-H., Hauser, M., Son, C., Naider, F. and Becker, J.M. 2002. Tyr266 in the Sixth Transmembrane Domain of the Yeast a-factor Receptor Plays Key Roles in Receptor Activation and Ligand Specificity. Biochemistry 41:13681-13689. (PubMed)

3. Celic, A., Martin, N.P., Son, C.D., Becker, J.M., Naider, F. and Dumont , M.E. 2003. Sequences in the intracellular loops of the yeast pheromone receptor Ste2p required for G protein activation. Biochemistry 42:3004-3017. (PubMed)

4. Naider, F., Ding, F.-D. VerBerkmoes , N.C. , Arshava, B., and Becker, J.M.. 2003. Synthesis and biophysical characterization of a multidomain peptide from a Saccharomyces cerevisiae G protein-coupled receptor. J. Biol. Chem. 278: 52537-52545. (PubMed)

5. Arevalo, E., Estephan, R., Madeo, J., Arshava, B., Dumont , M. , Becker, J.M., Naider, F. 2003. Biosynthesis and Biophysical Analysis of Domains of a Yeast G protein-coupled receptor. Biopolymers (Peptide Science) 71:516-531. (PubMed)

6. Naider, F., Estephan, R., Englander J., Suresh Babua, V.V., Arevalo, E., Samples, K. and Becker, J. M. 2004. Sexual Conjugation in Yeast: A Paradigm to Study G Protein-Coupled Receptor Domain Structure. Biopolymers (Peptide Science) 76: 119-128. (PubMed)

7. Bajaj, A., Ćelić, A., Ding, F.-D., Naider, F., Becker, J. M., and Dumont , M.E. 2004. A Fluorescent Tridecapeptide Analog Exhibits Multiple Steps on Binding to its G Protein-Coupled Receptor in Yeast. Biochemistry 43:13564-13578. (PubMed)

8. Son, C.D., Sargsyan, H., Naider, F. and Becker, J.M. 2004. Identification of ligand binding regions of the Saccharomyces cerevisiae a-factor pheromone receptor (Ste2p) by photo-affinity cross-linking. Biochemistry 43:13193-13203. (PubMed)

9. Becker, J. M. and Naider, F., 2004. The alpha-factor mating pheromone of Saccharomyces cerevisiae: a model for studying the interaction of peptide hormones and G protein-coupled receptors. Peptides 25:1441-1463. (PubMed)

10. Janiak, A. M., Sargsyan, H., Russo, J., Naider, F., Hauser, M. and Becker, J.M. 2005. Functional Expression of the Candida albicans a-factor receptor in Saccharomyces cerevisiae. Fungal Genetics & Biology 42:328-338. (PubMed)

Fungal pathogenesis/multidrug resistance

1. Gale, C. A., Bendel, C. M., McClellan, M., Hauser, M., Becker, J. M., Berman, J., and Hostetter, M. K. 1998. A single gene, INT1, links adhesion, filamentous growth, and virulence in Candida albicans. Science 279:1355-1358.(PubMed)

2. Forche, A., May, G., Beckerman, J., Kauffman, S., Becker, J., Magee, P.T. 2003. A system for studying genetic changes in Candida albicans during infection. Fungal Genet. Biol. 39:38-50. (PubMed)

3. Warenda, A. J., Kauffman, S., Sherrill, T.P., Becker, J. M., and Konopka, J. B. 2003. Candida albicans septin mutants are defective for invasive growth and virulence. Inf. Immun. 71:4045-4051. (PubMed)

4. Roemer, T., Jiang, B., Davison, J., Ketela, T., Veillete, K., Breton, A., Tandia. F., Linteau, A., Sillaots, S., Marta, C., Martel, N., Veronneau, S., Kauffman, S., Becker, J., Storms, R., Boone, C., and Bussey, H. 2003. Large-scale essential gene identification in Candida albicans and application to antifungal drug discovery. Mol. Microbiol. 50:167-181. (PubMed)

5. Liu, H., Kauffman, S., Becker, J.M., and Szaniszlo, P. 2004. WdChs5p of Wangiella (Exophiala) dermatitidis, a class V chitin synthase, is essential for sustained growth at temperature of infection. Eucaryotic Cell. 3:41-50. (PubMed)

Other Studies (Mass spectrometry, Genomics)

1. Sharp, J.S., Becker, J.M. and Robert L. Hettich, R.L. 2003. Protein Surface Mapping by Chemical Oxidation: Structural Analysis by Mass Spectrometry. Anal. Biochem. 313:216-225. (PubMed)

2. Chen, Y., Liu, Y., Goldstein, K.M., Becker, J.M., Xu, Y., and Xu, D. 2003. A Computational Study on the Signal Transduction Pathway for Amino Acid and Peptide Transport in Yeast: Bridging the Gap between High-Throughput Data and Traditional Biology. Applied Genomics and Proteomics, 2:43-50.

3. Sharp, J.S., Becker, J.M., and Hettich, R.L. 2004. Analysis of protein solvent accessible surfaces by photochemical oxidation and mass spectrometry. Anal. Chem. 76:672-683. (PubMed)

4. Joshi, T., Chen, Y., Becker, J.M., Alexandrov, N., and Xu, D. 2004. Genome-Scale Gene Function Prediction Using Multiple Sources of High-Throughput Data in Yeast Saccharomyces cerevisiae, OMICS. 8:322-333. (PubMed)

5. Masi, T., Cekanova, M., Walker , K., Bernert, H., Majidi, M., Becker, J. M., Schuller, H. M. 2005. Nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induced pulmonary adenocarcinomas in Syrian golden hamsters contain β2-adrenergic receptor single nucleotide polymorphisms (SNPs). Gene Chromosome Cancer, in press