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Center of Excellence for Structural Biology

Welcome to CESB

The mission of the UT Center of Excellence for Structural Biology (CESB) is to expand the frontiers of knowledge in biomolecular structural and functional research. The center will provide state-of-the-art infrastructure and education for scientists in all relevant departments at UT. The Center brings together a large group of structural molecular biologists working on a wide range of biological molecules, biomolecular assemblies and complexes. Its participants represent specialties in all of the current major techniques for high-resolution structure determination of large molecules, including X-ray crystallography, NMR spectroscopy and a battery of sophisticated biophysical tools including mass spectrometry and other spectroscopic techniques. In addition, the building of the world’s best accelerator-based, pulsed-neutron system, the Spallation Neutron Source (SNS), in Oak Ridge, will provide the members of the center a unique access to this source for neutron scattering and diffraction studies.

The Center’s overall thrust can be summarized as the Structural Basis of Biomolecular Recognition and Disease. The members of the Center fall in one or more of the following five emphasis areas:

I-Structure and Function of Disease-Related Molecules: Drug Targets, Drug Design, and Medicinal Chemistry-Drug Development.

II-Structure and Assembly of Macromolecules.

III-Signal Transduction and Membrane Transport.

IV-Computational Structural Biology.

V-Development of Novel Strategies, Tools and Techniques.



Center of Excellence for Structural Biology

M407 Walters Life Sciences Building
Knoxville, Tennessee 37996-0840

Phone: 865-974-5148
Fax: 865-974-6306