| The mission of the UT Center of
Excellence for Structural Biology (CESB) is to expand
the frontiers of knowledge in biomolecular structural
and functional research. The center will provide
state-of-the-art infrastructure and education for
scientists in all relevant departments at UT. The Center
brings together a large group of structural molecular
biologists working on a wide range of biological
molecules, biomolecular assemblies and complexes. Its
participants represent specialties in all of the current
major techniques for high-resolution structure
determination of large molecules, including X-ray
crystallography, NMR spectroscopy and a battery of
sophisticated biophysical tools including mass
spectrometry and other spectroscopic techniques. In
addition, the building of the world’s best
accelerator-based, pulsed-neutron system, the Spallation
Neutron Source (SNS), in Oak Ridge, will provide the
members of the center a unique access to this source for
neutron scattering and diffraction studies. The
Center’s overall thrust can be summarized as
the Structural Basis of Biomolecular Recognition and
Disease. The members of the Center fall in one or
more of the following five emphasis areas:
I-Structure and Function of Disease-Related
Molecules: Drug Targets, Drug Design, and Medicinal
Chemistry-Drug Development.
II-Structure and Assembly of Macromolecules.
III-Signal Transduction and Membrane Transport.
IV-Computational Structural Biology.
V-Development of Novel Strategies, Tools and
Techniques.
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