There are two main areas of research in my lab.
Chemokines are small chemotactic cytokines that are important in controlling leukocyte trafficking during innate, inflammatory, and adaptive immune responses. My work focuses on both human and murine cytomegaloviruses, investigating how these viruses use viral/host chemokines to alter the trafficking of immune cells for the viruses' benefit.
Chemokines and their receptors normally function in inflammatory, developmental, and homeostatic processes. Deregulation of this system is associated with the development of cancers and metastasis. Constitutively active chemokine receptor, CXCR2, continually induce a signal within a cell in the absence of ligand can lead to cellular transformation, the first steps in cancer development. We are currently investigating the important residues of CXCR2 responsible for activation. These discoveries may lead to the development of drugs to shutoff CXCR2s thus providing doctors with another weapon in their arsenal to treat melanomas or to decrease their metastatic potential.
More information, see lab page.
B.A., 1989, Northwestern University
Ph.D., 1996, Emory University
Postdoctoral Fellow, 1996-1999, Imperial College, London, UK
Postdoctoral Fellow, 1999-2003, Stanford University
M409 Walters Life Sciences
Knoxville, Tennessee 37996-0845
Knoxville, Tennessee 37996 | 865-974-1000
The flagship campus of the University of Tennessee System