Engin H. Serpersu
Professor
Department of Biochemistry Cellular and Molecular Biology
The University of Tennessee
Knoxville, TN 37922
email: serpersu@utk.edu
Phone: 865-974-2668
Office: Walters Life Sciences Bldg. M431A
Our laboratory studies interactions of aminoglycoside antibiotics with enzymes that modify these antibiotics and eliminate their antibacterial effects. Our work involves biophysical studies of enzyme-ligand complexes to determine global and site-specific structural, thermodynamic, and dynamic properties of these complexes to understand molecular principles that determine structural and energetic aspects of enzyme-antibiotic interactions.
